|
Title
|
|
|
|
Health-related quality of life and colorectal cancer-specific symptoms in patients with chemotherapy-refractory metastatic disease treated with panitumumab
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Purpose Panitumumab monotherapy is approved for chemotherapy-refractory wild-type KRAS metastatic colorectal cancer (mCRC). Patient-reported outcomesalthough important in the palliative settinghave not been reported in this patient population. Methods In a phase 3 trial (n = 463), patients with chemotherapy-refractory mCRC were randomized 1:1 to panitumumab plus best supportive care (BSC) or BSC alone. Patient-reported outcomes were assessed using the NCCN/FACT CRC Symptom Index (FCSI) and EQ-5D Index. KRAS tumor status was analyzed in a prospectively defined, retrospective analysis. Average difference in change from baseline between treatment groups was evaluated using linear mixed and pattern-mixture models. Results KRAS tumor status and post-baseline patient-reported outcomes were available for 363 patients. Linear mixed models indicated significant differences in the FCSI score (difference in least-squares [LS] adjusted means [95% CI]; 5.62 [2.38, 8.86]) and the EQ-5D Index (difference in LS adjusted means [95% CI]; 0.22 [0.12, 0.32]) favoring panitumumab over BSC in patients with wild-type KRAS mCRC. By pattern-mixture analysis, the advantage of panitumumab over BSC was more pronounced in those patients with wild-type KRAS mCRC who did not drop out of the study early. In patients with mutant KRAS mCRC, no differences were observed between groups. Conclusions Panitumumab-treated patients with wild-type KRAS mCRC maintained better control of CRC symptoms and quality of life compared with BSC alone, extending our understanding of the benefits of panitumumab treatment beyond improvements in progression-free survival. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
International journal of colorectal disease. - Berlin, 1986, currens
| |
|
Publication
|
|
|
|
Berlin
:
Springer
,
2011
| |
|
ISSN
|
|
|
|
0179-1958
[print]
1432-1262
[online]
| |
|
DOI
|
|
|
|
10.1007/S00384-010-1112-5
| |
|
Volume/pages
|
|
|
|
26
:2
(2011)
, p. 173-181
| |
|
ISI
|
|
|
|
000286467600006
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|