Title
Resequencing of positional candidates identifies low frequency **IL23R** coding variants protecting against inflammatory bowel disease Resequencing of positional candidates identifies low frequency **IL23R** coding variants protecting against inflammatory bowel disease
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Biology
Human medicine
Source (journal)
Nature genetics. - New York, N.Y.
Volume/pages
43(2011) :1 , p. 43-47
ISSN
1061-4036
ISI
000285683500013
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Genome-wide association studies (GWAS) have identified dozens of risk loci for many complex disorders, including Crohn's disease1, 2. However, common disease-associated SNPs explain at most ~20% of the genetic variance for Crohn's disease. Several factors may account for this unexplained heritability3, 4, 5, including rare risk variants not adequately tagged thus far in GWAS6, 7, 8. That rare susceptibility variants indeed contribute to variation in multifactorial phenotypes has been demonstrated for colorectal cancer9, plasma high-density lipoprotein cholesterol levels10, blood pressure11, type 1 diabetes12, hypertriglyceridemia13 and, in the case of Crohn's disease, for NOD2 (refs. 14,15). Here we describe the use of high-throughput resequencing of DNA pools to search for rare coding variants influencing susceptibility to Crohn's disease in 63 GWAS-identified positional candidate genes. We identify low frequency coding variants conferring protection against inflammatory bowel disease in IL23R, but we conclude that rare coding variants in positional candidates do not make a large contribution to inherited predisposition to Crohn's disease.
E-info
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