Publication
Title
In vitro antiplasmodial and cytotoxic activities of ethanol extracts of apical stem of **Phyllanthus amarus** Schum. et Thonn. (Euphorbiaceae)
Author
Abstract
The in vitro antiplasmodial and cytotoxic activities of ethanol extracts from whole plant, fresh apical stems and calli from fresh apical stem of Phyllanthus amarus cultured on Murashige and Skoog (MS) medium supplemented with indole-butyric acid (IBA)/benzylaminopurine (BAP) 1:1, 1:2, 1:4 and 1:4, IBA/BAP/mannitol 1:1:0.5%, IBA/BAP/mannitol: 2% for three months were evaluated. Results indicated that all ethanol extracts showed an in vitro antiplasmodial activity at different extends. The most active ethanol extract was that from callus cultivated with IBA/BAP/mannitol 1:1:05% (IC50 < 0.19 µg/ml). The ethanol whole plant and intact apical stem extracts exhibited an activity with IC50 values of 2.5 ± 0.4 and 8.2 ± 1.9 µg/ml, respectively. Quercetin, lupeol and ellagic acid displayed an antiplasmodial activity with IC50 values of 3.2 ± 0.6, 8.3 ± 1.4 and 0.07 ± 0.02 µg/ml, respectively. All ethanol extracts and isolated compounds were considered to be non cytotoxic against MT-4 cell lines growth (CC50 > 32 µg/ml).
Language
English
Source (journal)
Journal of Complementary and Integrative Medicine
Publication
2010
ISSN
15533840
Volume/pages
7:1(2010), p. 55
Article Reference
55
Medium
E-only publicatie
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Record
Identification
Creation 09.05.2011
Last edited 19.07.2016
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