Title
Development of mucoadhesive poly(lactide-co-glycolide) nanoparticles for ocular application Development of mucoadhesive poly(lactide-co-glycolide) nanoparticles for ocular application
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
New York ,
Subject
Pharmacology. Therapy
Source (journal)
Pharmaceutical development and technology. - New York
Volume/pages
16(2011) :1 , p. 29-35
ISSN
1083-7450
ISI
000286791400004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Pilocarpine loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by solvent evaporation method and coated with various mucoadhesive polymers, in particular chitosan, sodium alginate and poloxamers. The size of chitosan-coated nanoparticles was larger than the size of all the other particles obtained. Their surface charge was changed from negative (−22.8 mV) to positive (+61.0 mV). The interaction between mucin and chitosan-coated nanoparticles took place up to six hours according to turbidimetric study. The positive charge of chitosan-coated nanoparticles decreased significantly six hours after incubation in mucin dispersion, which was attributed to their electrostatic interaction. The coating with chitosan could be considered useful approach aiming to prolong nanoparticle residence time after local ocular application.
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