Title
Bladder pain syndrome : do the different morphological and cystoscopic features correlate? Bladder pain syndrome : do the different morphological and cystoscopic features correlate?
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Stockholm ,
Subject
Human medicine
Source (journal)
Scandinavian journal of urology and nephrology. - Stockholm
Volume/pages
45(2011) :1 , p. 20-23
ISSN
0036-5599
ISI
000287123700003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objective. For the diagnosis of bladder pain syndrome (BPS), the International Society for the Study of Bladder Pain Syndrome (ESSIC) recommends a specific diagnostic work-up using cystoscopy with hydrodistension and bladder biopsies. This study evaluates the correlation between the histological findings in bladder biopsies handled following ESSIC recommendations, as well as the importance of the histological features in BPS compared with the cystoscopic findings. Material and methods. The study included 15 men and 93 women. All patients underwent cystoscopy with hydrodistension, and at least three deep biopsies including detrusor muscle were taken. For the cell count the Leder stain was used most frequently. A cut-off point of 28 mast cells/mm2 was used for detrusor mastocytosis. Results. Significant correlations were found between urothelial damage and inflammatory infiltrate (p < 0.001). Detrusor mastocytosis was significantly more elevated in biopsies with normal urinary epithelium (Tukey corrected p < 0.0001) than in biopsies where the urothelium was damaged. No other correlations were found between histological findings or between histological and cystoscopic findings. Conclusion. Both cystoscopy with hydrodistension and histology can be used to illustrate different pathophysiological mechanisms in patients with BPS. These results favour the use of both in the classification of BPS patients.
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