Publication
Title
Central effects of occipital nerve electrical stimulation studied by functional magnetic resonance imaging
Author
Abstract
Objective:  To study the central effects of occipital nerve stimulation (ONS) using functional magnetic resonance imaging (fMRI). Materials and Methods:  After phantom measurements, blocked design fMRI scanning was performed during intermittent ONS in a healthy volunteer with implanted electrodes connected to an external generator. To assess the effect of frequency and stimulation mode, seven different frequencies in either tonic or burst mode were generated by a neurostimulator. Results:  A qualitative analysis of the main effect of ONS demonstrated significantly decreased activity within the bilateral primary visual, auditory, and somatosensory cortices and in the amygdala. Significant increased activity was observed bilaterally in the thalamus, frontal, and parietal areas and the cerebellum. Subsequently, quantitative analysis revealed that, unlike tonic mode stimulation, burst mode stimulation appeared to be frequency-dependent. Conclusions:  This study demonstrates the feasibility and safety of fMRI studies with simultaneous ONS in a subject with externalized electrodes. The activation and deactivation pattern induced by ONS depends on stimulation mode and frequency.
Language
English
Source (journal)
Neuromodulation. - Oxford
Publication
Oxford : 2011
ISSN
1094-7159
Volume/pages
14:1(2011), p. 46-55
ISI
000287317600016
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 13.05.2011
Last edited 06.08.2017
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