Title
Cell biological and physicochemical aspects of arterial calcificationCell biological and physicochemical aspects of arterial calcification
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Pathophysiology
Faculteit Geneeskunde
Publication type
article
Publication
New York, N.Y.,
Subject
Human medicine
Source (journal)
Kidney international / International Society of Nephrology. - New York, N.Y.
Volume/pages
79(2011):11, p. 1166-1177
ISSN
0085-2538
ISI
000290559400005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Processes similar to endochondral or intramembranous bone formation occur in the vascular wall. Bone and cartilage tissue as well as osteoblast- and chondrocyte-like cells are present in calcified arteries. As in bone formation, apoptosis and matrix vesicles play an important role in the initiation of vascular calcification. Recent evidence indicates that nanocrystals initially formed in the vessel wall may actively be involved in the progression of the calcification process. This review focuses on the cellular and structural similarities between bone formation and vascular calcification and discusses the initial events in this pathological mineralization process.
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