Title
The contribution of malaria in pregnancy to perinatal mortality The contribution of malaria in pregnancy to perinatal mortality
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Baltimore, Md ,
Subject
Human medicine
Source (journal)
The American journal of tropical medicine and hygiene. - Baltimore, Md
Volume/pages
71(2004) :S:2 , p. 35-40
ISSN
0002-9637
ISI
000223612900007
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
The link between malaria and perinatal mortality was explored by systematically reviewing 117 studies published between 1948 and 2002. The mean perinatal mortality rate was higher in malaria endemic countries (61.1/1,000, 95% confidence interval [CI] = 52.170.1) than in non-endemic countries (25.8/1,000, 95% CI = 21.130.6). Similarly, the fetal mortality rate was higher in endemic countries (40.1/1,000, 95% CI = 32.148.0) than in non-endemic countries (20.0/1,000, 95% CI = 13.226.8) countries. Considering that perinatal mortality is an important indicator of obstetric care quality and socioeconomic development, further analysis was restricted to countries with a human development index between 500 and 800. In this category, the perinatal mortality rate was also significantly higher in endemic countries (50.5/1,000, 95% CI = 35.565.5) than in non-endemic countries (30.0/1,000, 95% CI = 25.734.3). In some publications, the occurrence of placental malaria and stillbirth was available. Placental malaria was significantly associated with a higher risk for stillbirth, regardless of parity (odds ratio = 2.19, 95% CI = 1.493.22, P < 0.001). Despite the limitations involved in this kind of review, all information found indicates that in endemic countries, malaria is an important determinant of perinatal mortality. Preventive measures such as intermittent preventive treatment or insecticide-treated bed nets could substantially reduce perinatal mortality and fetal wastage.
E-info
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