Title
Increased risk for severe malaria in HIV-1infected adults, Zambia Increased risk for severe malaria in HIV-1infected adults, Zambia
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Atlanta, Ga ,
Subject
Human medicine
Source (journal)
Emerging infectious diseases / National Center for Infectious Diseases. Centers for Disease Control and Prevention. - Atlanta, Ga
Volume/pages
15(2009) :5 , p. 749-755
ISSN
1080-6040
ISI
000265518800009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
To determine whether HIV-1 infection and HIV-1related immunosuppression were risk factors for severe malaria in adults with some immunity to malaria, we conducted a casecontrol study in Luanshya, Zambia, during December 2005March 2007. For each case-patient with severe malaria, we selected 2 matched controls (an adult with uncomplicated malaria and an adult without signs of disease). HIV-1 infection was present in 93% of case-patients, in 52% of controls with uncomplicated malaria, and in 45% of asymptomatic controls. HIV-1 infection was a highly significant risk factor for adults with severe malaria compared with controls with uncomplicated malaria (odds ratio [OR] 12.6, 95% confidence interval [CI] 2.078.8, p = 0.0005) and asymptomatic controls (OR 16.6, 95% CI 2.5111.5, p = 0.0005). Persons with severe malaria were more likely to have a CD4 count <350/μL than were asymptomatic controls (OR 23.0, 95% CI 3.35158.00, p<0.0001).
Full text (open access)
https://repository.uantwerpen.be/docman/irua/117b3f/53e7db03.pdf
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