Title
Serum glutamine synthetase has no value as a diagnostic biomarker for Alzheimers disease Serum glutamine synthetase has no value as a diagnostic biomarker for Alzheimers disease
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
New York ,
Subject
Human medicine
Source (journal)
Neurochemical research. - New York
Volume/pages
36(2011) :10 , p. 1858-1862
ISSN
0364-3190
ISI
000294262600018
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In order to test whether serum glutamine synthetase (GS) is of potential diagnostic value for Alzheimers disease (AD), we set up a study to compare serum GS concentrations between AD patients and control subjects. The study population (n = 165) consisted of AD patients (n = 94) and age-matched (n = 41) and age-unmatched (n = 30) control subjects. Serum GS analysis was performed by means of ELISA. No significant differences in serum GS levels were found between the AD group and age-matched controls. Age correlated positively with serum GS concentrations in AD patients and control subjects. This study suggests that serum GS levels have no diagnostic value for AD.
E-info
https://repository.uantwerpen.be/docman/iruaauth/18bccc/65727376ba2.pdf
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