Title
Lower serum vitamin E concentrations in major depression : another marker of lowered antioxidant defenses in that illnessLower serum vitamin E concentrations in major depression : another marker of lowered antioxidant defenses in that illness
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Amsterdam,
Subject
Pharmacology. Therapy
Source (journal)
Journal of affective disorders. - Amsterdam
Volume/pages
58(2000):3, p. 241-246
ISSN
0165-0327
ISI
000087287900009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Objective: Major depression is associated with defective antioxidant defenses. Vitamin E is the major fat soluble antioxidant in the body. The aim of the present study is to examine serum vitamin E concentrations in major depressed patients versus normal volunteers. Method: Serum vitamin E concentrations were measured in 26 healthy volunteers and 42 major depressed patients by means of HPLC. Since vitamin E is a fat soluble vitamin, and serum vitamin E concentrations are strongly related to these of low-density-lipoprotein cholesterol (LDL-C) and triglycerides, we have adjusted the results for possible differences in these lipids. The numbers of peripheral blood leukocytes were measured. Results: Patients with major depression had significantly lower serum vitamin E concentrations than healthy controls. The area under the ROC (receiver operating characteristics) curve was 83%. There were significant and negative correlations between serum vitamin E and number of total leukocytes and neutrophils. Conclusions: Major depression is accompanied by significantly lower serum vitamin E concentrations, suggesting lower antioxidant defenses against lipid peroxidation. The results could, in part, explain previous findings, which suggest increased lipid peroxidation in major depression.
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