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Title
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Lower serum vitamin E concentrations in major depression : another marker of lowered antioxidant defenses in that illness
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Author
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Abstract
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| Objective: Major depression is associated with defective antioxidant defenses. Vitamin E is the major fat soluble antioxidant in the body. The aim of the present study is to examine serum vitamin E concentrations in major depressed patients versus normal volunteers. Method: Serum vitamin E concentrations were measured in 26 healthy volunteers and 42 major depressed patients by means of HPLC. Since vitamin E is a fat soluble vitamin, and serum vitamin E concentrations are strongly related to these of low-density-lipoprotein cholesterol (LDL-C) and triglycerides, we have adjusted the results for possible differences in these lipids. The numbers of peripheral blood leukocytes were measured. Results: Patients with major depression had significantly lower serum vitamin E concentrations than healthy controls. The area under the ROC (receiver operating characteristics) curve was 83%. There were significant and negative correlations between serum vitamin E and number of total leukocytes and neutrophils. Conclusions: Major depression is accompanied by significantly lower serum vitamin E concentrations, suggesting lower antioxidant defenses against lipid peroxidation. The results could, in part, explain previous findings, which suggest increased lipid peroxidation in major depression. |
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Language
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English
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Source (journal)
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Journal of affective disorders. - Amsterdam
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Publication
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Amsterdam
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2000
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ISSN
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0165-0327
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DOI
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10.1016/S0165-0327(99)00121-4
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Volume/pages
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58
:3
(2000)
, p. 241-246
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ISI
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000087287900009
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Full text (Publisher's DOI)
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