Publication
Title
Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery
Author
Abstract
Haptoglobin (Hp) 2-2 type has been associated with accumulation of atherosclerotic lesions in essential hypertension. The aim of this study was to investigate the relationship between Hp type and the extension of coronary lesions in 765 male patients who underwent coronary artery bypass grafting (CABG). In this group, relative Hp1 (0.418) and Hp2 (0.582) allele frequencies were comparable with those of the reference population. Candidate CABG patients with a Hp 2-2 type were overrepresented in the younger (<45 years) age group (P<0.05). Hp 2-2 patients needed more bypass grafts than Hp 1-1 patients (relative risk 1.92, 95% C.I. 1.242.96). The Hp 2-2 type was overrepresented among victims of a previous acute myocardial infarction (P<0.05), and among patients with a lower (<45 years) age at infarction (P<0.05). In patients who already underwent a previous CABG, graft survival time was shortest in Hp 2-2 type (P<0.05). Patients with a Hp 2-2 type more likely develop atherosclerotic lesions despite comparable serum lipid concentrations.
Language
English
Source (journal)
Atherosclerosis. - Amsterdam
Publication
Amsterdam : 1997
ISSN
0021-9150
Volume/pages
132:2(1997), p. 215-219
ISI
A1997XL44700011
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 30.05.2011
Last edited 27.05.2017