Publication
Title
Excess serum osmolality gap after ingestion of methanol : a methodology- associated phenomenon?
Author
Abstract
A patient intentionally ingested an unknown amount of methanol and was admitted to the hospital 6 h later. On admission, the methanol concentration in blood was estimated as approximately of 134 mmol/L, based on the calculation of the osmolal gap. Intravenous ethanol administration and hemodialysis were promptly started. During hemodialysis, several blood samples were collected for determination of methanol and ethanol concentrations. Initially, we used gas chromatography with split-mode injection of pretreated serum samples; however, methanol concentrations turned out to be significantly lower than expected, based on calculated osmolal gap values. Because no explanation for the excess serum osmolal gap was apparent, we reanalyzed samples, using head-space gas chromatography. The methanol concentrations measured were significantly higher and osmolal gap values were no longer excessive.
Language
English
Source (journal)
Clinical chemistry : international journal of laboratory medicine and molecular diagnostics / American Association of Clinical Chemists. - Winston-Salem, N.C., 1955, currens
Publication
Winston-Salem, N.C. : 1994
ISSN
0009-9147 [print]
1530-8561 [online]
Volume/pages
40:8(1994), p. 1587-1590
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Record
Identification
Creation 30.05.2011
Last edited 02.09.2016