Title
Antiprotozoal and antiangiogenic saponins from **Apodytes dimidiata** Antiprotozoal and antiangiogenic saponins from **Apodytes dimidiata**
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Oxford ,
Subject
Chemistry
Biology
Pharmacology. Therapy
Source (journal)
Phytochemistry: an international journal of plant biochemistry. - Oxford
Volume/pages
72(2011) :11/12 , p. 1414-1423
ISSN
0031-9422
ISI
000293323800011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Bioassay-guided isolation was performed on the leaves of Apodytes dimidiata E. Mey. Ex Arn. (Icacinaceae), based on previously demonstrated activity against Leishmania. Six saponins never isolated from nature before were elucidated with LCMS/MS, GCMS and 1D and 2D NMR. The compounds apodytine AF are responsible at least in part for the antiprotozoal activity, but also possess haemolytic activity and display antiangiogenic activity in the rat aorta ring assay, an effect which may be due to a non-selective toxicity.
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