Publication
Title
Antiprotozoal and antiangiogenic saponins from **Apodytes dimidiata**
Author
Abstract
Bioassay-guided isolation was performed on the leaves of Apodytes dimidiata E. Mey. Ex Arn. (Icacinaceae), based on previously demonstrated activity against Leishmania. Six saponins never isolated from nature before were elucidated with LCMS/MS, GCMS and 1D and 2D NMR. The compounds apodytine AF are responsible at least in part for the antiprotozoal activity, but also possess haemolytic activity and display antiangiogenic activity in the rat aorta ring assay, an effect which may be due to a non-selective toxicity.
Language
English
Source (journal)
Phytochemistry: an international journal of plant biochemistry. - Oxford
Publication
Oxford : 2011
ISSN
0031-9422
Volume/pages
72:11/12(2011), p. 1414-1423
ISI
000293323800011
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 31.05.2011
Last edited 24.06.2017
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