Title
Theta-gamma dysrhythmia and auditory phantom perception Theta-gamma dysrhythmia and auditory phantom perception
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Charlottesville, Va ,
Subject
Human medicine
Source (journal)
Journal of neurosurgery. - Charlottesville, Va, 1944, currens
Volume/pages
114(2011) :4 , p. 912-921
ISSN
0022-3085
1933-0693
ISI
000288725900005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Tinnitus is considered an auditory phantom percept analogous to phantom pain. Thalamocortical dysrhythmia has been proposed as a possible pathophysiological mechanism for both tinnitus and pain. Thalamocortical dysrhythmia refers to a persistent pathological resting state theta-gamma coupling that is spatially localized at an area where normally alpha oscillations predominate. Auditory cortex stimulation via implanted electrodes has been developed to treat tinnitus, targeting an area of activation on functional MR imaging elicited by tinnitus-matched sound presentation. The authors describe a case in which clinical improvement was correlated with changes in intracranial recordings. Maximal tinnitus suppression was obtained by current delivery exactly at the blood oxygen leveldependent activation hotspot, which colocalizes with increased gamma and theta activity, in contrast to the other electrode poles, which demonstrated a normal alpha peak. These spectral changes normalized when stimulation induced tinnitus suppression, both on electrode and source-localized electroencephalography recordings. These data suggest that thetagamma coupling as proposed by the thalamocortical dysrhythmia model might be causally related to a conscious auditory phantom percept.
E-info
https://repository.uantwerpen.be/docman/iruaauth/3dd8da/092448582b9.pdf
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