Title
Protein complexes gain momentum Protein complexes gain momentum
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
London ,
Subject
Chemistry
Source (journal)
Current opinion in structural biology. - London
Volume/pages
12(2002) :6 , p. 729-734
ISSN
0959-440X
ISI
000179777100006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The greatest challenge to structural biologists in the post-genomic era is to decipher both stable and transient interactions of protein complexes. In response to this challenge, significant advances in mass spectrometry have been made in the past two years. With the inception of novel approaches targeted at defining interaction partners, stoichiometry and topology, as well as monitoring real-time reactions, mass spectrometry is well placed to contribute to the understanding of dynamic macromolecular complexes.
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