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Title
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Laser desorption mass spectrometry on thin liquid jets
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Author
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Abstract
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| A recently developed soft desorption method for mass spectrometry is presented, which is called Laser Induced Liquid Beam Ionization/Desorption (LILBID). Analyte ions are desorbed from a thin jet of analyte solution directly into vacuum by means of an IR laser pulse, which has been tuned to a vibrational resonance of the solvent. A comparative experiment with ammonium chloride and aniline hydrochloride shows that ion formation via proton transfer takes place in the solution. Thermally unstable compounds, as well as supra- and biomolecular complexes, can be detected intact and mass analyzed in a reflectron time-of-flight (Re-TOF) mass spectrometer. During the desorption process, noncovalent interactions and some solvation characteristics are preserved. Three examples for the capacity of LILBID are given in this short overview: (a) ion-solvent interactions with the formation of a clathrate structure Cs+(H2O)20, (b) host-guest interactions with the K+ selectivity of valinomycin, and (c) noncovalent interactions with the dimerization of gramicidin. |
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Language
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English
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Source (journal)
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Fresenius' journal of analytical chemistry. - Heidelberg, 1990 - 2001
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Publication
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Heidelberg
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Springer
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1997
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ISSN
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0937-0633
[print]
1432-1130
[online]
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DOI
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10.1007/S002160050798
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Volume/pages
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360
:7/8
(1998)
, p. 745-749
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ISI
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000073112200002
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Full text (Publisher's DOI)
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