Title
Laser desorption mass spectrometry on thin liquid jets Laser desorption mass spectrometry on thin liquid jets
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Berlin ,
Subject
Chemistry
Source (journal)
Fresenius' journal of analytical chemistry. - Berlin, 1990 - 2001
Volume/pages
360(1998) :7/8 , p. 745-749
ISSN
0937-0633
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
A recently developed soft desorption method for mass spectrometry is presented, which is called Laser Induced Liquid Beam Ionization/Desorption (LILBID). Analyte ions are desorbed from a thin jet of analyte solution directly into vacuum by means of an IR laser pulse, which has been tuned to a vibrational resonance of the solvent. A comparative experiment with ammonium chloride and aniline hydrochloride shows that ion formation via proton transfer takes place in the solution. Thermally unstable compounds, as well as supra- and biomolecular complexes, can be detected intact and mass analyzed in a reflectron time-of-flight (Re-TOF) mass spectrometer. During the desorption process, noncovalent interactions and some solvation characteristics are preserved. Three examples for the capacity of LILBID are given in this short overview: (a) ion-solvent interactions with the formation of a clathrate structure Cs+(H2O)20, (b) host-guest interactions with the K+ selectivity of valinomycin, and (c) noncovalent interactions with the dimerization of gramicidin.