Publication
Title
Corticotrophin-releasing factor, related peptides, and receptors in the normal and inflamed gastrointestinal tract
Author
Abstract
Corticotrophin-releasing factor (CRF) is mainly known for its role in the stress response in the hypothalamicpituitaryadrenal axis. However, increasing evidence has revealed that CRF receptor signaling has additional peripheral effects. For instance, activation of CRF receptors in the gastrointestinal tract influences intestinal permeability and motility. These receptors, CRF1 and CRF2, do not only bind CRF, but are also activated by urocortins. Most interestingly, CRF-related signaling also assumes an important role in inflammatory bowel diseases in that it influences inflammatory processes, such as cytokine secretion and immune cell activation. These effects are characterized by an often contrasting function of CRF1 and CRF2. We will review the current data on the expression of CRF and related peptides in the different regions of the gastrointestinal tract, both in normal and inflamed conditions. We next discuss the possible functional roles of CRF signaling in inflammation. The available data clearly indicate that CRF signaling significantly influences inflammatory processes although there are important species and inflammation model differences. Although further research is necessary to elucidate this apparently delicately balanced system, it can be concluded that CRF-related peptides and receptors are (certainly) important candidates in the modulation of gastrointestinal inflammation.
Language
English
Source (journal)
Frontiers in neuroscience. - Lausanne
Publication
Lausanne : 2011
ISSN
1662-4548
Volume/pages
5(2011), p. 54,1-54,14
ISI
000209200600050
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.07.2011
Last edited 10.07.2017
To cite this reference