Title
Eosinophil cationic protein and clinical outcome after bare metal stent implantationEosinophil cationic protein and clinical outcome after bare metal stent implantation
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Translational Pathophysiological Research (TPR)
Publication type
article
Publication
Amsterdam,
Subject
Human medicine
Source (journal)
Atherosclerosis. - Amsterdam
Volume/pages
215(2011):1, p. 166-169
ISSN
0021-9150
ISI
000288008700024
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Objective we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. Methods basal ECP levels were measured in 110 patients (69 ± 11 years, 88 men) undergoing BMS implantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. Results eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.847.3) vs. 9.5 (5.027.2) g/L, p = 0.02]. At follow-up, ECP level >11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.110.4, p = 0.03). Conclusion basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.
E-info
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