Title
Dual association of a TRKA polymorphism with schizophrenia Dual association of a TRKA polymorphism with schizophrenia
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Londen ,
Subject
Human medicine
Source (journal)
Psychiatric genetics. - Londen
Volume/pages
21(2011) :3 , p. 125-131
ISSN
0955-8829
ISI
000289770400002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objective: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. Methods: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia casecontrol groups. Result: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. Conclusion: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.
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