|
Title
|
|
|
|
Dual association of a TRKA polymorphism with schizophrenia
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| Objective: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. Methods: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia casecontrol groups. Result: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. Conclusion: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Psychiatric genetics. - Londen
|
|
|
Publication
|
|
|
|
Londen
:
2011
|
|
|
ISSN
|
|
|
|
0955-8829
|
|
|
DOI
|
|
|
|
10.1097/YPG.0B013E3283437194
|
|
|
Volume/pages
|
|
|
|
21
:3
(2011)
, p. 125-131
|
|
|
ISI
|
|
|
|
000289770400002
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|