Publication
Title
Dual association of a TRKA polymorphism with schizophrenia
Author
Abstract
Objective: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. Methods: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia casecontrol groups. Result: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. Conclusion: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.
Language
English
Source (journal)
Psychiatric genetics. - Londen
Publication
Londen : 2011
ISSN
0955-8829
Volume/pages
21:3(2011), p. 125-131
ISI
000289770400002
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 05.07.2011
Last edited 23.06.2017
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