Correlations between dysglycemia, markers of oxidative stress and inflammation in diabetic foot patients
Faculty of Medicine and Health Sciences
Farmacia. - Bucure«015F»ti
, p. 216-227
University of Antwerp
Impaired glucose metabolism, dyslipidemia and chronic inflammation are present in diabetes mellitus. Ulceration of the foot in diabetes is common and disabling and frequently leads to amputation of the leg. The aim of this study was to assess the relationship between fasting plasma glucose (FPG), postprandial plasma glucose (PPG), plasma lipids and inflammation markers in diabetic foot patients. Hospitalised diabetic foot patients (n=12), diagnosed with diabetes mellitus type 2, for less than 6 years, who havent yet received insulin as treatment, were included. Spectrophotometric and HPLC methods were used to assess plasma studied parameters. Significant correlations (r with values between 0.81 and 0.94, for p<0.05) were calculated between LDL (low-density lipoprotein) cholesterol and: haptoglobin, ceruloplasmin, lipid peroxides, FPG, uric acid, glycosylated hemoglobin (HbA1c), plasma dicarbonyls and fructosamine. Atherogenic index was positively correlated (r with values between 0.74 and 0.88, for p < 0.05) with: haptoglobin, ceruloplasmin, lipid peroxides, leukocytes, HbA1c, triglycerides. The leukocytes were correlated with acute phase proteins (r = 0.82 with Creactive protein and r=0.81 with haptoglobin). PPG didnt correlate with any of the above markers. Glucose metabolism was revealed by the average values: HbA1c = 10.14 %, FPG = 144 mg/dL, dicarbonyls = 0.49 μmol/L and fructosamine 256.17 μmol/L. This pilot study underlines the strong correlations between precursors of AGE (advanced glycation end-products), dyslipidemia markers and acute phase proteins in a group of type 2 diabetic foot patients with incorrect glycaemic control and duration of diabetes for less than six years. Atherogenic index correlated with all the pathogenic markers in diabetes mellitus demonstrates the strong link between atherosclerosis and the diabetic foot complication.