Treating humoral rejection after cardiac transplantationTreating humoral rejection after cardiac transplantation
Doorn-Janssen, van, Karin
Faculty of Medicine and Health Sciences
Translational Pathophysiological Research (TPR)
Acta cardiologica. - Bruxelles
66(2011):2, p. 263-266
University of Antwerp
Whereas effective strategies are available to treat acute cellular cardiac rejection, humoral rejection, also called vascular or antibody-mediated rejection, is more difficult to manage. Antibody-mediated (non-cellular) rejections (AMR) are rare and few successfully treated cases have been described in the literature. We report on a female patient, diagnosed with humoral rejection, leading to severe ventricular dysfunction and haemodynamic compromise, two months after transplantation. The patient received a combination therapy, consisting of plasmapheresis and immunoglobulins, which resulted in complete resolution of immunohistochemical signs of AMR. In this report, we will overview AMR and discuss several treatment modalities.