Title
Estimation of transmission parameters of a fluoroquinolone-resistant **Escherichia coli** strain between pigs in experimental conditions Estimation of transmission parameters of a fluoroquinolone-resistant **Escherichia coli** strain between pigs in experimental conditions
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Paris ,
Subject
Veterinary medicine
Source (journal)
Veterinary research. - Paris
Volume/pages
42(2011) :1 , p. 44,1-44,7
ISSN
0928-4249
ISI
000290662000003
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Antimicrobial resistance is of primary importance regarding public and animal health issues. Persistence and spread of resistant strains within a population contribute to the maintenance of a reservoir and lead to treatment failure. An experimental trial was carried out to study the horizontal transmission of a fluoroquinolone-resistant Escherichia coli strain from inoculated to naïve pigs. All naïve contact pigs had positive counts of fluoroquinolone-resistant E. coli after only two days of contact. Moreover, re-infections of inoculated pigs caused by newly contaminated animals were suspected. A maximum likelihood method, based on a susceptible-infectious-susceptible (SIS) model, was used to determine the transmission parameters. Two transmission levels were identified depending on the quantity of bacteria shed by infected individuals: (i) low-shedders with bacterial counts of resistant E. coli in the faeces between 5*103 and 106 CFU/g (βL = 0.41 [0.27; 0.62]), (ii) high shedders with bacterial counts above 106 CFU/g (βH = 0.98 [0.59; 1.62]). Hence, transmission between animals could be pivotal in explaining the persistence of resistant bacteria within pig herds.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/32aa92/11af7ac1.pdf
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