|
Title
|
|
|
|
Estimation of transmission parameters of a fluoroquinolone-resistant **Escherichia coli** strain between pigs in experimental conditions
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Antimicrobial resistance is of primary importance regarding public and animal health issues. Persistence and spread of resistant strains within a population contribute to the maintenance of a reservoir and lead to treatment failure. An experimental trial was carried out to study the horizontal transmission of a fluoroquinolone-resistant Escherichia coli strain from inoculated to naïve pigs. All naïve contact pigs had positive counts of fluoroquinolone-resistant E. coli after only two days of contact. Moreover, re-infections of inoculated pigs caused by newly contaminated animals were suspected. A maximum likelihood method, based on a susceptible-infectious-susceptible (SIS) model, was used to determine the transmission parameters. Two transmission levels were identified depending on the quantity of bacteria shed by infected individuals: (i) low-shedders with bacterial counts of resistant E. coli in the faeces between 5*103 and 106 CFU/g (βL = 0.41 [0.27; 0.62]), (ii) high shedders with bacterial counts above 106 CFU/g (βH = 0.98 [0.59; 1.62]). Hence, transmission between animals could be pivotal in explaining the persistence of resistant bacteria within pig herds. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Veterinary research. - Paris
| |
|
Publication
|
|
|
|
Paris
:
2011
| |
|
ISSN
|
|
|
|
0928-4249
1297-9716
| |
|
DOI
|
|
|
|
10.1186/1297-9716-42-44
| |
|
Volume/pages
|
|
|
|
42
:1
(2011)
, p. 44,1-44,7
| |
|
Article Reference
|
|
|
|
44
| |
|
ISI
|
|
|
|
000290662000003
| |
|
Medium
|
|
|
|
E-only publicatie
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (open access)
|
|
|
|
| |
|