Title
Cell of origin of small cell lung cancer : inactivation of **Trp53** and **Rb1** in distinct cell types of adult mouse lung Cell of origin of small cell lung cancer : inactivation of **Trp53** and **Rb1** in distinct cell types of adult mouse lung
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Cambridge, Mass. ,
Subject
Veterinary medicine
Source (journal)
Cancer cell. - Cambridge, Mass.
Volume/pages
19(2011) :6 , p. 754-764
ISSN
1535-6108
ISI
000291839500009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Small cell lung cancer (SCLC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we assessed the effect of Trp53 and Rb1 inactivation in distinct cell types in the adult lung using adenoviral vectors that target Cre recombinase to Clara, neuroendocrine (NE), and alveolar type 2 (SPC-expressing) cells. Using these cell type-restricted Adeno-Cre viruses, we show that loss of Trp53 and Rb1 can efficiently transform NE and SPC-expressing cells leading to SCLC, albeit SPC-expressing cells at a lesser efficiency. In contrast, Clara cells were largely resistant to transformation. The results indicate that although NE cells serve as the predominant cell of origin of SCLC a subset of SPC-expressing cells are also endowed with this ability.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/ac88b5/5015.pdf
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