Publication
Title
Cell of origin of small cell lung cancer : inactivation of **Trp53** and **Rb1** in distinct cell types of adult mouse lung
Author
Abstract
Small cell lung cancer (SCLC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we assessed the effect of Trp53 and Rb1 inactivation in distinct cell types in the adult lung using adenoviral vectors that target Cre recombinase to Clara, neuroendocrine (NE), and alveolar type 2 (SPC-expressing) cells. Using these cell type-restricted Adeno-Cre viruses, we show that loss of Trp53 and Rb1 can efficiently transform NE and SPC-expressing cells leading to SCLC, albeit SPC-expressing cells at a lesser efficiency. In contrast, Clara cells were largely resistant to transformation. The results indicate that although NE cells serve as the predominant cell of origin of SCLC a subset of SPC-expressing cells are also endowed with this ability.
Language
English
Source (journal)
Cancer cell. - Cambridge, Mass.
Publication
Cambridge, Mass. : 2011
ISSN
1535-6108
Volume/pages
19:6(2011), p. 754-764
ISI
000291839500009
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 28.07.2011
Last edited 04.12.2017
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