Title
Prognostic value of gastric intramural pH in surgical intensive care patients Prognostic value of gastric intramural pH in surgical intensive care patients
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Baltimore, Md ,
Subject
Pharmacology. Therapy
Source (journal)
Critical care medicine / Society of Critical Care Medicine [Anaheim, Calif.] - Baltimore, Md, 1973, currens
Volume/pages
16(1988) :12 , p. 1222-1224
ISSN
0090-3493
1530-0293
Carrier
E
Target language
English (eng)
Abstract
AB Gastric intramural pH (pHi), which has been shown to reflect the adequacy of oxygenation in peripheral tissue beds, was measured in acutely ill surgical patients in order to evaluate its value as a prognostic factor and its relation to the sepsis score. Fifty-nine surgical patients were studied on ICU admission. The stomach wall pH was calculated from the Pco2 in gastric juice and arterial bicarbonate concentration using the Henderson-Hasselbach equation. A fall in tissue pH < 7.32 was taken as an indication of inadequate tissue oxygenation. Patients with sepsis scores >10 were considered septic. Hospital and short-term (within 72 h of admission) mortality rates were determined. A significantly higher short-term mortality rate was observed in patients having a pHi <7.32 (37% vs. 0%, p < .005). Most (90%) of the septic patients had a pHi <7.32. The short-term mortality rate was the highest (50%) in the septic group. In this group also, a linear correlation was found between pHi and the sepsis score (r = -.43, p < .01). Gastric pHi, however, offered no prediction for the long-term outcome.