Title
Chromosome rearrangement in **Leishmania mexicana** M379 Chromosome rearrangement in **Leishmania mexicana** M379
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Molecular and biochemical parasitology. - Amsterdam
Volume/pages
46(1991) :1 , p. 53-60
ISSN
0166-6851
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Circular extrachromosomal elements were observed in a variety of Leishmania species. We show here that two lines originating from the same isolate have been found to contain a circular DNA molecule of 26.6 kb and a linear chromosome of about 250 kb, respectively, which share a homology of more than 20 kb. The circular DNA molecule and its related region on the linear chromosome were cloned and their restriction maps compared. This investigation reveals information about chromosome rearrangement in L. mexicana M379. Further examination will enable us to understand the nature of chromosome rearrangement such as circularization or linearization.