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Title
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Comparison of chromosome and isoenzyme polymorphism in geographical populations of **Leishmania (Viannia) peruviana**
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Author
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Abstract
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| Five chromosomes and 17 isoenzyme loci were analysed in 4 allopatric populations of Leishmania (Viannia) peruviana, and molecular distances calculated with 2 estimators, Chromosomal Size Difference Index and Jaccard Distance. Chromosome and isoenzyme data were in overall concordance: 13/30 isolates clustered similarly on the dendrograms constructed from the different estimators, and a significant correlation (P<0·001) was observed between the molecular distances calculated from the two sets of characters. This indicates an evolutionary association between chromosomal size polymorphism and isoenzymes. Chromosomes have a faster molecular clock than isoenzymes; twice as many genotypes were identified by chromosome analysis and significant size differences (for a total of up to 500 kb for 5 chromosomes together) were observed within a given zymodeme. Chromosomes most likely represent better indicators of genetic drift than isoenzymes, as suggested by the higher correlation between both estimators of chromosomal size-polymorphism and eco-geography. Some chromosomes might present an adaptive response to environmental variation. |
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Language
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English
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Source (journal)
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Parasitology. - London, 1908, currens
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Publication
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London
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1998
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ISSN
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0031-1820
[print]
1469-8161
[online]
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Volume/pages
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117
:6
(1998)
, p. 547-554
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