Publication
Title
How to succeed in parasitic life without sex? Asking **Leishmania**
Author
Abstract
Eukaryotes use sexual recombination to achieve innovation and adaptation to a changing environment, a mechanism that is exceptional in Leishmania. It is postulated that asexual mechanisms contribute efficiently to parasite fitness and that sexual recombination would not be necessary for the production of a large repertoire of genotypes. The model discussed in this review used a major Leishmania glycoprotein, gp63, which is involved in hostparasite relationships. Mitotic recombination, which occurs between and within tandem repeats, amplifies genes and generates genotypic diversity. The resulting variation in the protein sequence is concentrated in surface domains, in regions spanning T-cell epitopes and B-cell epitopes and might allow immune escape.
Language
English
Source (journal)
Trends in parasitology. - London
Publication
London : 2001
ISSN
1471-4922
Volume/pages
18:2(2001), p. 81-85
ISI
000173624600009
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 04.08.2011
Last edited 05.08.2017