Title
Restaging the mediastinum in non-small cell lung cancer after induction therapy : non-invasive versus invasive procedures Restaging the mediastinum in non-small cell lung cancer after induction therapy : non-invasive versus invasive procedures
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Brussel ,
Subject
Human medicine
Source (journal)
Acta chirurgica Belgica. - Brussel, 1946 - 1996
Volume/pages
111(2011) :3 , p. 161-164
ISSN
0001-5458
ISI
000292524700008
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Objective : Nodal status after induction therapy in patients with stage III non-small cell lung cancer (NSCLC) is an independent prognostic factor for survival. Prognosis is poor in patients with persisting mediastinal lymph node involvement. Methods : From February 2000 to September 2007, restaging for NSCLC was performed in 25 patients (23 men, 2 women) by computed tomography (CT), positron emission tomography (PET) as well as repeat mediastinoscopy. Initial proof of N2 or N3 disease was obtained by mediastinoscopy. Results : The non-invasive restaging modalities CT and PET had a rather low accuracy of 64% and 72%, respectively. Repeat mediastinoscopy performed better with an accuracy of 84%. Conclusion : Histological proof of mediastinal involvement after induction therapy in NSCLC is necessary to select those patients who will benefit from surgical resection. When a first mediastinoscopy has been performed to obtain pathological proof of N2 or N3 disease, repeat mediastinoscopy proves to be more accurate than CT or PET scanning for mediastinal restaging.
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