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Title
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Fine tuning of the Van Nuys Prognostic Index (VNPI) 2003 by integrating the Genomic Grade Index (GGI) : new tools for Ductal Carcinoma In Situ (DCIS)
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Author
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Abstract
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| Ductal carcinoma in situ (DCIS) is considered a heterogeneous premalignant condition of the breast with a certain probability for progressing to malignancy. There is no standard of care. The updated Van Nuys Prognostic Index (VNPI) 2003 is a clinical tool in treatment decision making. This study assessed the prognostic value of the VNPI after integration of proliferative biomarkers (GGI and Ki-67). DCIS samples were divided into three VNPI subgroups (low risk [score 46], intermediate risk [score 79], high risk [score 1012]) based on nuclear grade ± necrosis, tumor size, margin width, and age. Nuclear grade was substituted by the genomic grade index (GGI) to generate the VNPI-GGI and combined with the Ki-67 to generate the VNPI-Ki67. Disease-free survival was calculated by KaplanMeier survival plots with log-rank significance. Multiple regression analysis was carried out using Cox proportional hazard regression analysis. A total of 88 cases (median age 54 years) with representative tissue were identified out of 168 DCIS patients. Median follow-up was more than 5 years. Ten patients developed an ipsilateral recurrence of whom nine were invasive: six patients were classified in the VNPI subgroup 2 and three patients in the VNPI subgroup 3. One non-invasive recurrence (DCIS) was classified in the VNPI subgroup III. A statistical association was observed between a high VNPI score and a higher risk of recurrence (HR = 7.72 [95% CI 1.0158.91], p = 0.049). Ki-67 did not improve the prognostic value of VNPI (HR = 6.5, [95% CI 0.8053.33], p = 0.08). In contrast, the VNPI-GGI could identify more accurately high-risk DCIS patients with early relapses within 5 years (HR = 18.14 [95% CI 1.75188], p = 0.015). GGI incorporated into the VNPI improved its prognostic value for DCIS, especially for identifying early relapses. This method should be validated and incorporated in future prospective clinical DCIS trials. |
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Language
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Dutch
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Source (journal)
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Breast journal. - Oxford
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Publication
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Oxford
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2011
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ISSN
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1075-122X
[print]
1524-4741
[online]
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DOI
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10.1111/J.1524-4741.2011.01091.X
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Volume/pages
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17
:4
(2011)
, p. 343-351
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ISI
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000292743100003
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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