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Title
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Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)
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Author
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Abstract
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| Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate pathway of isoprenoid biosynthesis and a potential antimalarial target, were synthesized and biologically evaluated. The binding mode of one derivative in complex with EcIspC and a divalent metal ion was clarified by X-ray analysis. Pilot experiments have demonstrated in vivo potential. |
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Language
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English
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Source (journal)
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Journal of medicinal chemistry. - Washington, D.C., 1963, currens
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Publication
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Washington, D.C.
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2011
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ISSN
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0022-2623
[print]
1520-4804
[online]
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DOI
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10.1021/JM200694Q
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Volume/pages
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54
:19
(2011)
, p. 6796-6802
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ISI
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000295546200033
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Full text (Publisher's DOI)
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