Publication
Title
Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)
Author
Abstract
Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate pathway of isoprenoid biosynthesis and a potential antimalarial target, were synthesized and biologically evaluated. The binding mode of one derivative in complex with EcIspC and a divalent metal ion was clarified by X-ray analysis. Pilot experiments have demonstrated in vivo potential.
Language
English
Source (journal)
Journal of medicinal chemistry. - Washington, D.C., 1963, currens
Publication
Washington, D.C. : 2011
ISSN
0022-2623
Volume/pages
54:19(2011), p. 6796-6802
ISI
000295546200033
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 05.09.2011
Last edited 30.05.2017
To cite this reference