Publication
Title
Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimers disease diagnosis : a consensus paper from the Alzheimers Biomarkers Standardization Initiative
Author
Abstract
Background Numerous studies show that the cerebrospinal fluid biomarkers total tau (T-tau), tau phosphorylated at threonine 181 (P-tau181P), and amyloid-β (1-42) (Aβ142) have high diagnostic accuracy for Alzheimers disease. Variability in concentrations for Aβ142, T-tau, and P-tau181P drives the need for standardization. Methods Key issues were identified and discussed before the first meeting of the members of the Alzheimers Biomarkers Standardization Initiative (ABSI). Subsequent ABSI consensus meetings focused on preanalytical issues. Results Consensus was reached on preanalytical issues such as the effects of fasting, different tube types, centrifugation, time and temperature before storage, storage temperature, repeated freeze/thaw cycles, and length of storage on concentrations of Aβ142, T-tau, and P-tau181P in cerebrospinal fluid. Conclusions The consensus reached on preanalytical issues and the recommendations put forward during the ABSI consensus meetings are presented in this paper.
Language
English
Source (journal)
Alzheimer's & dementia. - Place of publication unknown
Publication
New york : Elsevier science inc, 2012
ISSN
1552-5260
Volume/pages
8:1(2012), p. 65-73
ISI
000299586900008
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.11.2011
Last edited 13.11.2017
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