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Title
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Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimers disease diagnosis : a consensus paper from the Alzheimers Biomarkers Standardization Initiative
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Author
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Abstract
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| Background Numerous studies show that the cerebrospinal fluid biomarkers total tau (T-tau), tau phosphorylated at threonine 181 (P-tau181P), and amyloid-β (1-42) (Aβ142) have high diagnostic accuracy for Alzheimers disease. Variability in concentrations for Aβ142, T-tau, and P-tau181P drives the need for standardization. Methods Key issues were identified and discussed before the first meeting of the members of the Alzheimers Biomarkers Standardization Initiative (ABSI). Subsequent ABSI consensus meetings focused on preanalytical issues. Results Consensus was reached on preanalytical issues such as the effects of fasting, different tube types, centrifugation, time and temperature before storage, storage temperature, repeated freeze/thaw cycles, and length of storage on concentrations of Aβ142, T-tau, and P-tau181P in cerebrospinal fluid. Conclusions The consensus reached on preanalytical issues and the recommendations put forward during the ABSI consensus meetings are presented in this paper. |
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Language
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English
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Source (journal)
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Alzheimer's & dementia / Alzheimer’s Association [Chicago, Ill.] - Orlando, Fla, 2005, currens
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Publication
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New york
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Elsevier science inc
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2012
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ISSN
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1552-5260
[print]
1552-5279
[online]
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DOI
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10.1016/J.JALZ.2011.07.004
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Volume/pages
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8
:1
(2012)
, p. 65-73
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ISI
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000299586900008
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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