Publication
Title
Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population
Author
Abstract
Mitochondrial DNA (mtDNA) mutations have been implicated in various age-related diseases. To further clarify the role of mtDNA variants in age-related hearing impairment (ARHI), we determined the DNA sequence of the entire mitochondrial genome of 400 individuals using the Affymetrix Human Mitochondrial Resequencing Array. These were the 200 worst hearing and the 200 best hearing from a collection of 947 Belgian samples. We performed association tests with individual mitochondrial variants, comparison of the mutation load, and association with European haplogroups and their interaction with environmental risk factors. We also tested the influence of rare variants on ARHI. None of these tests showed any association with ARHI.
Language
English
Source (journal)
Mitochondrion. - Riverwood, Md
Publication
Riverwood, Md : 2011
ISSN
1567-7249
Volume/pages
11:5(2011), p. 729-734
ISI
000294089000008
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.11.2011
Last edited 09.08.2017
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