Title
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Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)
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Author
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Abstract
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In this Letter, we report on diarylpyridinone, diarylpyridazinone and diarylphthalazinone analogs as potential inhibitors of HIV-1 nonnucleoside reverse transcriptase (NNRTIs). The most promising compounds in these series are three diarylpyridazinones 25a, 25l and 25n which demonstrated submicromolar activity against wild-type HIV-1 and moderate activity against the single mutant strain Ba-L V106A. |
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Language
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English
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Source (journal)
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Bioorganic and medicinal chemistry. - Oxford
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Publication
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Oxford
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2011
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ISSN
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0968-0896
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DOI
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10.1016/J.BMC.2011.08.060
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Volume/pages
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19
:20
(2011)
, p. 5924-5934
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ISI
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000295494600001
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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