Title
Replacing vascular corrosion casting by in vivo micro-CT imaging for building 3D cardiovascular models in mice Replacing vascular corrosion casting by in vivo micro-CT imaging for building 3D cardiovascular models in mice
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Faculty of Medicine and Health Sciences
Publication type
article
Publication
,
Subject
Biology
Human medicine
Source (journal)
Molecular imaging and biology. - Place of publication unknown
Volume/pages
13(2011) :1 , p. 78-86
ISSN
1536-1632
ISI
000286395600011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Purpose The purpose of this study was to investigate if in vivo micro-computed tomography (CT) is a reliable alternative to micro-CT scanning of a vascular corrosion cast. This would allow one to study the early development of cardiovascular diseases. Procedures Datasets using both modalities were acquired, segmented, and used to generate a 3D geometrical model from nine mice. As blood pool contrast agent, Fenestra VC-131 was used. Batsons No. 17 was used as casting agent. Computational fluid dynamics simulations were performed on both datasets to quantify the difference in wall shear stress (WSS). Results Aortic arch diameters show 30% to 40% difference between the Fenestra VC-131 and the casted dataset. The aortic arch bifurcation angles show less than 20% difference between both datasets. Numerically computed WSS showed a 28% difference between both datasets. Conclusions Our results indicate that in vivo micro-CT imaging can provide an excellent alternative for vascular corrosion casting. This enables follow-up studies.
E-info
https://repository.uantwerpen.be/docman/iruaauth/305be7/7dea444f603.pdf
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