Title
Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London ,
Subject
Biology
Human medicine
Source (journal)
Molecular cancer. - London
Volume/pages
9(2010) , p. 219,1-219,14
ISSN
1476-4598
Article Reference
219
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Background The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimental models that mimic the natural pathogenesis of hepatocellular carcinoma (HCC) in a short time period is present. The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC. Methods Weekly intraperitoneal injections with the hepatocarcinogenic compound N-nitrosodiethylamine was applied as induction method and samples were taken at several time points to assess the angiogenic changes during the progression of HCC. Results The N-nitrosodiethylamine-induced mouse model provides well vascularised orthotopic tumours after 25 weeks. It is a representative model for human HCC and can serve as an excellent platform for the development of new therapeutic targets.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/c42c61/455e53f3.pdf