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Title
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Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
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Author
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Abstract
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| Background The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimental models that mimic the natural pathogenesis of hepatocellular carcinoma (HCC) in a short time period is present. The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC. Methods Weekly intraperitoneal injections with the hepatocarcinogenic compound N-nitrosodiethylamine was applied as induction method and samples were taken at several time points to assess the angiogenic changes during the progression of HCC. Results The N-nitrosodiethylamine-induced mouse model provides well vascularised orthotopic tumours after 25 weeks. It is a representative model for human HCC and can serve as an excellent platform for the development of new therapeutic targets. |
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Language
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English
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Source (journal)
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Molecular cancer. - London
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Publication
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London
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2010
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ISSN
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1476-4598
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DOI
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10.1186/1476-4598-9-219
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Volume/pages
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9
(2010)
, p. 219,1-219,14
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Article Reference
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219
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ISI
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000282461100001
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Pubmed ID
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20727157
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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