Title
Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford ,
Subject
Veterinary medicine
Source (journal)
Research in veterinary science. - Oxford
Volume/pages
91(2011) :3 , p. e125-e128
ISSN
0034-5288
ISI
000209482600025
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Given its importance in human and canine tumour biology, a profound understanding of tumour hypoxia is of paramount importance. Therefore, the aim of this work was to investigate the relationship between tumour hypoxia and the expression of a number of hypoxia-induced proteins that play a role in tumour metabolism. The hypoxia marker pimonidazole was administered to dogs affected by spontaneous mammary carcinoma and compared with immunohistochemical staining for GLUT1 and 3, HK 2 and CA IX. A statistically significant correlation was found between pimonidazole staining and GLUT1-expression (R = 0.607; p = 0.001). These results indicate a strong interaction between tumour hypoxia and tumour metabolism by the induction of proteins essential to maintain a stable tumour microenvironment.
E-info
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