Publication
Title
Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma
Author
Abstract
Given its importance in human and canine tumour biology, a profound understanding of tumour hypoxia is of paramount importance. Therefore, the aim of this work was to investigate the relationship between tumour hypoxia and the expression of a number of hypoxia-induced proteins that play a role in tumour metabolism. The hypoxia marker pimonidazole was administered to dogs affected by spontaneous mammary carcinoma and compared with immunohistochemical staining for GLUT1 and 3, HK 2 and CA IX. A statistically significant correlation was found between pimonidazole staining and GLUT1-expression (R = 0.607; p = 0.001). These results indicate a strong interaction between tumour hypoxia and tumour metabolism by the induction of proteins essential to maintain a stable tumour microenvironment.
Language
English
Source (journal)
Research in veterinary science. - Oxford
Publication
Oxford : 2011
ISSN
0034-5288
Volume/pages
91:3(2011), p. e125-e128
ISI
000209482600025
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 16.11.2011
Last edited 01.11.2017