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Title
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Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma
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Author
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Abstract
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| Given its importance in human and canine tumour biology, a profound understanding of tumour hypoxia is of paramount importance. Therefore, the aim of this work was to investigate the relationship between tumour hypoxia and the expression of a number of hypoxia-induced proteins that play a role in tumour metabolism. The hypoxia marker pimonidazole was administered to dogs affected by spontaneous mammary carcinoma and compared with immunohistochemical staining for GLUT1 and 3, HK 2 and CA IX. A statistically significant correlation was found between pimonidazole staining and GLUT1-expression (R = 0.607; p = 0.001). These results indicate a strong interaction between tumour hypoxia and tumour metabolism by the induction of proteins essential to maintain a stable tumour microenvironment. |
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Language
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English
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Source (journal)
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Research in veterinary science. - Oxford
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Publication
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Oxford
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2011
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ISSN
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0034-5288
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DOI
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10.1016/J.RVSC.2011.01.014
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Volume/pages
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91
:3
(2011)
, p. e125-e128
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ISI
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000209482600025
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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