Title
Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Copenhagen ,
Subject
Human medicine
Source (journal)
Acta neurologica Scandinavica. - Copenhagen
Volume/pages
121(2010) :4 , p. 271-276
ISSN
0001-6314
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Objective   The precise mechanism of action of vagus nerve stimulation (VNS) in suppressing epileptic seizures remains to be elucidated. This study investigates whether VNS modulates cortical excitability by determining the threshold for provoking focal motor seizures by cortical electrical stimulation before and after VNS. Material and methods   Male Wistar rats (n = 8) were implanted with a cuff-electrode around the left vagus nerve and with stimulation electrodes placed bilaterally on the rat motor cortex. Motor seizure threshold (MST) was assessed for each rat before and immediately after 1 h of VNS with standard stimulation parameters, during two to three sessions on different days. Results   An overall significant increase of the MST was observed following 1 h of VNS compared to the baseline value (1420 μA and 1072 μA, respectively; P < 0.01). The effect was reproducible over time with an increase in MST in each experimental session. Conclusions   VNS significantly increases the MST in a cortical stimulation model for motor seizures. These data indicate that VNS is capable of modulating cortical excitability.
E-info
https://repository.uantwerpen.be/docman/iruaauth/8569f2/665aa11ada9.pdf