Title
Deep Brain Stimulation for epilepsy : knowledge gained from experimental animal models Deep Brain Stimulation for epilepsy : knowledge gained from experimental animal models
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Bruxelles ,
Subject
Human medicine
Source (journal)
Acta neurologica Belgica. - Bruxelles
Volume/pages
109(2009) :2 , p. 63-80
ISSN
0300-9009
2240-2993
Carrier
E
Target language
English (eng)
Abstract
Since the development of Deep Brain Stimulation (DBS) for Parkinsons Disease, DBS has been suggested as a treatment option for various other neurological disorders. Stimulation of deep brain structures for refractory epilepsy appears to be a safe treatment option with promising results. As research on the evaluation and optimization of DBS for refractory epilepsy may be difficult and unethical in patients, studies on animal models of epilepsy are indispensable. Various brain structures and specific nuclei such as the basal ganglia, the cerebellum, the locus coeruleus and temporal lobe structures have been investigated as target areas for DBS. Additionally, a wide variety of stimulation parameters are available, with a range of stimulation frequencies, pulse widths and stimulation intensities. This review provides an overview of the relevant literature on experimental animal studies of DBS for epilepsy. Knowledge gained from animal studies can be used to answer questions regarding the optimal brain targets and stimulation parameters in human applications.
E-info
https://repository.uantwerpen.be/docman/iruaauth/dda9d4/b9fa3de24d1.pdf