Publication
Title
Deep Brain Stimulation for epilepsy : knowledge gained from experimental animal models
Author
Abstract
Since the development of Deep Brain Stimulation (DBS) for Parkinsons Disease, DBS has been suggested as a treatment option for various other neurological disorders. Stimulation of deep brain structures for refractory epilepsy appears to be a safe treatment option with promising results. As research on the evaluation and optimization of DBS for refractory epilepsy may be difficult and unethical in patients, studies on animal models of epilepsy are indispensable. Various brain structures and specific nuclei such as the basal ganglia, the cerebellum, the locus coeruleus and temporal lobe structures have been investigated as target areas for DBS. Additionally, a wide variety of stimulation parameters are available, with a range of stimulation frequencies, pulse widths and stimulation intensities. This review provides an overview of the relevant literature on experimental animal studies of DBS for epilepsy. Knowledge gained from animal studies can be used to answer questions regarding the optimal brain targets and stimulation parameters in human applications.
Language
English
Source (journal)
Acta neurologica Belgica. - Bruxelles
Publication
Bruxelles : 2009
ISSN
0300-9009 [print]
2240-2993 [online]
Volume/pages
109:2(2009), p. 63-80
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Record
Identification
Creation 16.11.2011
Last edited 02.09.2016