Title
Tumor cells and tumor-associated macrophages : secreted proteins as potential targets for therapy Tumor cells and tumor-associated macrophages : secreted proteins as potential targets for therapy
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Taylor ,
Subject
Human medicine
Source (journal)
Clinical and developmental immunology. - -
Volume/pages
(2011) , p. 565187,1-565187,12
ISSN
1740-2522
1740-2522
Article Reference
565187
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Inflammatory pathways, meant to defend the organism against infection and injury, as a byproduct, can promote an environment which favors tumor growth and metastasis. Tumor-associated macrophages (TAMs), which constitute a significant part of the tumor-infiltrating immune cells, have been linked to the growth, angiogenesis, and metastasis of a variety of cancers, most likely through polarization of TAMs to the M2 (alternative) phenotype. The interaction between tumor cells and macrophages provides opportunities for therapy. This paper will discuss secreted proteins as targets for intervention.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/a686aa/bb6545b5.pdf
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