Title
PopAffiliator : online calculator for individual affiliation to a major population group based on 17 autosomal short tandem repeat genotype profile PopAffiliator : online calculator for individual affiliation to a major population group based on 17 autosomal short tandem repeat genotype profile
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Berlin ,
Subject
Law
Human medicine
Source (journal)
International journal of legal medicine. - Berlin
Volume/pages
125(2011) :5 , p. 629-636
ISSN
0937-9827
ISI
000293910900002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Because of their sensitivity and high level of discrimination, short tandem repeat (STR) maker systems are currently the method of choice in routine forensic casework and data banking, usually in multiplexes up to 1517 loci. Constraints related to sample amount and quality, frequently encountered in forensic casework, will not allow to change this picture in the near future, notwithstanding the technological developments. In this study, we present a free online calculator named PopAffiliator (http://cracs.fc.up.pt/popaffiliator) for individual population affiliation in the three main population groups, Eurasian, East Asian and sub-Saharan African, based on genotype profiles for the common set of STRs used in forensics. This calculator performs affiliation based on a model constructed using machine learning techniques. The model was constructed using a data set of approximately fifteen thousand individuals collected for this work. The accuracy of individual population affiliation is approximately 86%, showing that the common set of STRs routinely used in forensics provide a considerable amount of information for population assignment, in addition to being excellent for individual identification.
E-info
https://repository.uantwerpen.be/docman/iruaauth/add984/2ef33705dd3.pdf
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Handle