Title
Developmental regulation of CYCA2s contributes to tissue-specific proliferation in **Arabidopsis** Developmental regulation of CYCA2s contributes to tissue-specific proliferation in **Arabidopsis**
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Heidelberg ,
Subject
Chemistry
Biology
Human medicine
Source (journal)
The EMBO journal. - Heidelberg, 1982, currens
Volume/pages
30(2011) :16 , p. 3430-3441
ISSN
0261-4189
1460-2075
ISI
000293971300018
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2;3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development.
E-info
https://repository.uantwerpen.be/docman/iruaauth/ca5ef0/459271eec1b.pdf
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