Title
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Developmental regulation of CYCA2s contributes to tissue-specific proliferation in **Arabidopsis**
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Author
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Abstract
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In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2;3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development. |
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Language
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English
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Source (journal)
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The EMBO journal. - Heidelberg, 1982, currens
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Publication
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Heidelberg
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2011
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ISSN
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0261-4189
[print]
1460-2075
[online]
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DOI
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10.1038/EMBOJ.2011.240
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Volume/pages
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30
:16
(2011)
, p. 3430-3441
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ISI
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000293971300018
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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