Title
Summary of effectiveness and impact of rotavirus vaccination with the oral pentavalent rotavirus vaccine : a systematic review of the experience in industrialized countriesSummary of effectiveness and impact of rotavirus vaccination with the oral pentavalent rotavirus vaccine : a systematic review of the experience in industrialized countries
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Human vaccines
Volume/pages
7(2011):7, p. 734-748
ISSN
1554-8600
1554-8619
ISI
000294453300012
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The pentavalent rotavirus (RV) vaccine RotaTeq has been available in industrialized countries since 2006. Several studies have been conducted to evaluate the benefit of RV vaccination under routine conditions of use. A systematic review of all publicly available data from RotaTeq vaccine-effectiveness and vaccination-impact studies in the USA, Europe and Australia between 2006 and February 2010 was undertaken. Depending on the population studied, effectiveness of up to 100% (95% confidence interval 85100%) associated with decreased hospitalizations for RV gastroenteritis (RVGE) was seen. Vaccination-impact studies demonstrated that the burden of RVGE has been reduced significantly since the introduction of RV vaccination. Evidence included reductions in healthcare utilization due to RVGE (hospitalizations and emergency-department visits reduced by up to 90%), reductions in the magnitude and duration of the RV season as assessed by laboratory testing for RV, and the possible induction of herd immunity.
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