Title
IL28B polymorphism and the control of hepatitis C virus infection : ready for clinical use? IL28B polymorphism and the control of hepatitis C virus infection : ready for clinical use?
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Bruxelles ,
Subject
Human medicine
Source (journal)
Acta gastro-enterologica belgica. - Bruxelles, 1946 - 1995
Volume/pages
74(2011) :2 , p. 317-322
ISSN
0001-5644
ISI
000293670600007
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin. The eventual role of the IL28B genotype in new therapeutic regimes with direct antiviral agents needs to be explored in the ongoing and future clinical studies with these agents.
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