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Title
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Synthesis of (hetero)arylated pyridazin-3(2H)-ones via Negishi reaction involving zincated pyridazin-3(2H)-ones
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Author
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Abstract
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| Zincated pyridazin-3(2H)-ones generated via brominemagnesium exchange followed by transmetalation using ZnCl2 or via lactam-directed ortho C4-H zincation with TMPZnCl·LiCl have been synthesized. These in situ created organometallics can be used in Negishi reactions with iodo(hetero)arenes delivering a new approach toward (hetero)arylpyridazin-3(2H)-ones. |
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Language
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English
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Source (journal)
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The journal of organic chemistry. - Washington, D.C., 1936, currens
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Publication
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Washington, D.C.
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2011
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ISSN
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0022-3263
[print]
1520-6904
[online]
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DOI
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10.1021/JO201587J
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Volume/pages
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76
:23
(2011)
, p. 9648-9659
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ISI
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000297274800012
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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