Publication
Title
Integrated dataset of screening hits against multiple neglected disease pathogens
Author
Abstract
New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. Our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative, multi-pathogen approach.
Language
English
Source (journal)
PLoS neglected tropical diseases
Publication
2011
ISSN
1935-2727
Volume/pages
5:12(2011), p. 1-10
Article Reference
e1412
ISI
000298667700018
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 22.12.2011
Last edited 09.12.2017
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