Publication
Title
Neurons and a subset of interstitial cells of cajal in the enteric nervous system highly express stam2 gene
Author
Abstract
Signal transducing adaptor molecule 2 (STAM2) is a phosphotyrosine protein, which is a member of the endosomal sorting complex required for transport (ESCRT-0) and is involved in the sorting process of the mono-ubiquitinated endosomal cargo for degradation in the lysosome. Analysis of gene trap mice carrying lacZ in frame with Stam2 revealed beta-galactosidase activity in the enteric nervous system (both in the myenteric and submucosal plexus) throughout the digestive tract. STAM2 immunostaining confirmed that the observed beta-galactosidase activity coincided with high Stam2 expression. To identify cell types with high Stam2 expression, STAM2 immunostaining was colocalized with the neuronal markers microtubule-associated protein 2 and protein gene product 9.5 and with c-kit as a marker for interstitial cells of Cajal (ICCs). STAM2 and c-kit positive cells comprised a subset of ICCs in the enteric nervous system. Qualitative and quantitative analysis of the morphology of the enteric nervous system in the homozygous mice carrying gene trap insertion in the Stam2 gene did not reveal phenotype changes; therefore, STAM2 function in the digestive tube remains elusive.
Language
English
Source (journal)
The anatomical record: advances in integrative anatomy and evolutionary biology. - New York, N.Y.
Publication
New York, N.Y. : 2012
ISSN
1932-8486
Volume/pages
295:1(2012), p. 113-120
ISI
000298090200014
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 02.01.2012
Last edited 04.10.2017
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