Title
Host interactions of probiotic bacterial surface molecules : comparison with commensals and pathogens Host interactions of probiotic bacterial surface molecules : comparison with commensals and pathogens
Author
Faculty/Department
Faculty of Sciences. Bioscience Engineering
Publication type
article
Publication
London ,
Subject
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
Nature reviews: microbiology. - London
Volume/pages
8(2010) :3 , p. 171-184
ISSN
1740-1526
ISI
000274565400009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
How can probiotic bacteria transduce their health benefits to the host? Bacterial cell surface macromolecules are key factors in this beneficial microorganismhost crosstalk, as they can interact with host pattern recognition receptors (PRRs) of the gastrointestinal mucosa. In this Review, we highlight the documented signalling interactions of the surface molecules of probiotic bacteria (such as long surface appendages, polysaccharides and lipoteichoic acids) with PRRs. Research on hostprobiotic interactions can benefit from well-documented hostmicroorganism studies that span the spectrum from pathogenicity to mutualism. Distinctions and parallels are therefore drawn with the interactions of similar molecules that are presented by gastrointestinal commensals and pathogens.
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