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Title
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Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase : peering into the mechanism of aromatase inhibition
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Author
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Abstract
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| Aromatase (CYP19A1), is a microsomal cytochrome P450 catalysing the conversion of androgens to estrogens. Non-steroidal inhibitors, such as anastrozole, are important drugs in breast cancer therapy. Using hyperfine sublevel correlation (HYSCORE) spectroscopy we provide the first experimental evidence of the binding of anastrozole to the iron heme of human aromatase. |
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Language
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English
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Source (journal)
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Chemical communications / Royal Society of Chemistry [London] - London, 1996, currens
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Publication
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London
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Royal Society of Chemistry
,
2011
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ISSN
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1359-7345
[print]
1364-548X
[online]
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DOI
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10.1039/C1CC13872C
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Volume/pages
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47
:37
(2011)
, p. 10737-10739
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ISI
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000295004300066
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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