Publication
Title
Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase : peering into the mechanism of aromatase inhibition
Author
Abstract
Aromatase (CYP19A1), is a microsomal cytochrome P450 catalysing the conversion of androgens to estrogens. Non-steroidal inhibitors, such as anastrozole, are important drugs in breast cancer therapy. Using hyperfine sublevel correlation (HYSCORE) spectroscopy we provide the first experimental evidence of the binding of anastrozole to the iron heme of human aromatase.
Language
English
Source (journal)
ChemComm / Royal Society of Chemistry [London] - London, 1996, currens
Publication
London : 2011
ISSN
1359-7345 [print]
1364-548X [online]
Volume/pages
47:37(2011), p. 10737-10739
ISI
000295004300066
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.01.2012
Last edited 26.06.2017
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