Title
Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase : peering into the mechanism of aromatase inhibition Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase : peering into the mechanism of aromatase inhibition
Author
Faculty/Department
Faculty of Sciences. Physics
Publication type
article
Publication
London ,
Subject
Chemistry
Source (journal)
ChemComm. - London, 1996, currens
Volume/pages
47(2011) :37 , p. 10737-10739
ISSN
1359-7345
1364-548X
ISI
000295004300066
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Aromatase (CYP19A1), is a microsomal cytochrome P450 catalysing the conversion of androgens to estrogens. Non-steroidal inhibitors, such as anastrozole, are important drugs in breast cancer therapy. Using hyperfine sublevel correlation (HYSCORE) spectroscopy we provide the first experimental evidence of the binding of anastrozole to the iron heme of human aromatase.
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