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Title
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Evaluation of the **in vivo** anti-inflammatory activity of a flavonoid glycoside from **Boldoa purpurascens**
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Author
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Abstract
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| The anti-inflammatory effect of 4′,5-dihydroxy-6,7-methylenedioxyflavonol 3-O-α-l-rhamnopyranosyl-(1 → 2)-β-d-xylopyranoside, a constituent of the leaves of Boldoa purpurascens Cav. (Nyctaginaceae), was evaluated for its anti-inflammatory activity in the dextran 1% induced rat paw oedema model (acute inflammation) and the cotton pellet induced granuloma rat model (chronic inflammation). Flavonoid glycoside at doses of 2.5, 5 and 10 mg/kg, indomethacin at a dose of 7 mg/kg and the vehicle were administered orally. The compound showed significant anti-inflammatory activity in the acute phase in a dose dependent manner, most notably at the highest test dose 10 mg/kg. Also in the cotton pellet induced granuloma model, the compound showed a dose-dependent anti-inflammatory activity, with the highest effect at 10 mg/kg. In both assays, the test compound was more active than indomethacin tested at 7 mg/kg. |
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Language
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English
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Source (journal)
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Phytochemistry letters
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Publication
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2011
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ISSN
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1874-3900
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DOI
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10.1016/J.PHYTOL.2011.04.004
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Volume/pages
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4
:3
(2011)
, p. 231-234
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ISI
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000296534500006
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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